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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

《医学前沿（英文）》 2023年 第17卷 第1期   页码 75-84 doi: 10.1007/s11684-022-0950-1

摘要： This retrospective single-center registry study included all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesion using drug coated-balloon (DCB)-only strategy between August 2011 and December 2018. To best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main coronary artery disease, exist. The primary endpoint was major adverse cardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). The cohort was divided into two groups depending on weather the lesion preparation was done according to the international consensus group guidelines. Sixty-six patients (mean age 75±8.6, 72% male), 52% of whom had acute coronary syndrome, underwent left main PCI with the DCB-only strategy. No procedural mortality and no acute closures of the treated left main occurred. At 12 months, MACE and TLR occurred in 24% and 6% of the whole cohort, respectively. If the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2% and 1.9%. Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one year, if the lesion preparation is done according to the guidelines.

关键词： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary intervention    

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Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical

Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang

《化学科学与工程前沿（英文）》 2021年 第15卷 第1期   页码 148-155 doi: 10.1007/s11705-020-2022-x

摘要： In this paper, two carbon-coated lithium titanate (LTO-C1 and LTO-C2) composites were synthesized using the ball-milling-assisted calcination method with different carbon precursor addition processes. The physical and electrochemical properties of the as-synthesized negative electrode materials were characterized to investigate the effects of two carbon-coated LTO synthesis processes on the electrochemical performance of LTO. The results show that the LTO-C2 synthesized by using Li CO and TiO as the raw materials and sucrose as the carbon source in a one-pot method has less polarization during lithium insertion and extraction, minimal charge transfer impedance value and the best electrochemical performance among all samples. At the current density of 300 mA·h·g , the LTO-C2 composite delivers a charge capacity of 126.9 mA·h·g , and the reversible capacity after 300 cycles exceeds 121.3 mA·h·g in the voltage range of 1.0–3.0 V. Furthermore, the electrochemical impedance spectra show that LTO-C2 has higher electronic conductivity and lithium diffusion coefficient, which indicates the advantages in electrode kinetics over LTO and LTO-C1. The results clarify the best electrochemical properties of the carbon-coated LTO-C2 composite prepared by the one-pot method.

关键词： lithium titanate     carbon-coated     carbon precursor     synthetic process    

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Carbon-coated Ni-Co alloy catalysts: preparation and performance for aqueous phase hydrodeoxygenation

《化学科学与工程前沿（英文）》 2022年 第16卷 第3期   页码 443-460 doi: 10.1007/s11705-021-2079-1

摘要： Carbon-coated Ni, Co and Ni-Co alloy catalysts were prepared by the carbonization of the metal doped resorcinol-formaldehyde resins synthesized by the one-pot extended Stöber method. It was found that the introduction of Co remarkably reduced the carbon microsphere size. The metallic Ni, Co, and Ni-Co alloy particles (mainly 10–12 nm) were uniformly distributed in carbon microspheres. A charge transfer from Ni to Co appeared in the Ni-Co alloy. Compared with those of metallic Ni and Co, the d-band center of the Ni-Co alloy shifted away from and toward the Fermi level, respectively. In the in-situ aqueous phase hydrodeoxygenation of methyl palmitate with methanol as the hydrogen donor at 330 °C, the decarbonylation/decarboxylation pathway dominated on all catalysts. The Ni-Co@C catalysts gave higher activity than the Ni@C and Co@C catalysts, and the yields of n-pentadecane and n-C6–n-C16 reached 71.6% and 92.6%, respectively. The excellent performance of Ni-Co@C is attributed to the electronic interactions between Ni and Co and the small carbon microspheres. Due to the confinement effect of carbon, the metal particles showed high resistance to sintering under harsh hydrothermal conditions. Catalyst deactivation is due to the carbonaceous deposition, and the regeneration with CO2 recovered the catalyst reactivity.

关键词： Stöber method     carbon-coated Ni-Co alloy     in-situ hydrodeoxygenation     methyl palmitate     decarbonylation/decarboxylation    

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Spray-coated SnO

Yaqin Wang, Lin Yang, Chunxiang Dall’Agnese, Gang Chen, Ai-Jun Li, Xiao-Feng Wang

《化学科学与工程前沿（英文）》 2021年 第15卷 第1期   页码 180-186 doi: 10.1007/s11705-020-1917-x

摘要： SnO has been proven to be an effective electron transport layer (ETL) material for perovskite solar cells (PSCs) owing to its excellent electrical and optical properties. Here, we introduce a viable spray coating method for the preparation of SnO films. Then, we employ a SnO film prepared using the spray coating method as an ETL for PSCs. The PSC based on the spray-coated SnO ETL achieves a power conversion efficiency of 17.78%, which is comparable to that of PSCs based on conventional spin-coated SnO films. The large-area SnO films prepared by spray coating exhibit good repeatability for device performance. This study shows that SnO films prepared by spray coating can be applied as ETLs for stable and high-efficiency PSCs. Because the proposed method involves low material consumption, it enables the low-cost and large-scale production of PSCs.

关键词： spray coating     SnO2 film     ETL     PSCs    

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Taking advantage of drug resistance, a new approach in the war on cancer

null

《医学前沿（英文）》 2018年 第12卷 第4期   页码 490-495 doi: 10.1007/s11684-018-0647-7

摘要：

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.

关键词： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

《化学科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 116-122 doi: 10.1007/s11705-013-1310-0

摘要： Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy- -PMA). Various grades of Psy- -PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

关键词： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Development of highly active coated monolith SCR catalyst with strong abrasion resistance for low-temperature

Lina GAN,Shan LEI,Jian YU,Hongtao MA,Yo YAMAMOTO,Yoshizo SUZUKI,Guangwen XU,Zhanguo ZHANG

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 979-987 doi: 10.1007/s11783-015-0824-8

摘要： Monolith SCR catalysts coated with V O -WO /TiO were prepared by varying binder and coating thickness. Comparing with a monolith extruded with 100% V O -WO /TiO powder, a coated monolith with a catalyst-coating layer of 260 μm in thickness exhibited the similar initial NO reduction activity at 250°C. After 4 h abrasion (attrition) in an air stream containing 300 g·m fine sands (50–100 μm) at a superficial gas velocity of 10 m·s , the catalyst still has the activity as a 100% molded monolith does in a 24-h activity test and it retains about 92% of its initial activity at 250°C. Estimation of the equivalent durable hours at a fly ash concentration of 1.0 g·m in flue gas and a gas velocity of 5 m·s demonstrated that this coated monolith catalyst is capable of resisting abrasion for 13 months without losing more than 8% of its initial activity. The result suggests the great potential of the coated monolith for application to de-NO of flue gases with low fly ash concentrations from, such as glass and ceramics manufacturing processes.

关键词： coated monolith     low-temperature denitration     abrasion resistance     attrition    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

《化学科学与工程前沿（英文）》 2010年 第4卷 第1期   页码 82-86 doi: 10.1007/s11705-009-0307-1

摘要： A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drug delivery (PDD). This technique, based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF process. An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.

关键词： advanced engineering     improved     pressure     aqueous     technique    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

《化学科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 225-232 doi: 10.1007/s11705-014-1429-7

摘要： Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

关键词： controlled release     drug delivery     semi-solids     polymer     excipient    

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

《化学科学与工程前沿（英文）》 2012年 第6卷 第3期   页码 246-252 doi: 10.1007/s11705-012-1299-9

摘要： A solvothermal method has been successfully used to prepare nanostructured hydroxyapatite (HA) hollow spheres with average diameters of about 500 nm and shell thicknesses of about 100 nm in a glycerin/water mixed solvent. Transmission electron microscopy (TEM) and field-emission scanning electron microscopy (FESEM) images show that the shells of the HA hollow spheres are actually composed of nanosheets with thicknesses of about 10 nm. By tuning the glycerin/water volume ratio, two other kinds of HA solid spheres with average diameters of about 6 or 20 μm were assembled from nanoflakes. The properties of the different kinds of spheres as drug delivery carriers were evaluated. Ibuprofen (IBU) was chosen as the model drug to load into the HA samples. The nanostructured HA samples showed a slow and sustained release of IBU. The HA hollow spheres exhibited a higher drug loading capacity and more favorable release properties than the HA solid spheres and thus are very promising for controlled drug release applications.

关键词： hydroxyapatite     hollow spheres     synthesis     drug release    

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Performance of activated carbon coated graphite bipolar electrodes on capacitive deionization method

Hossein D. Atoufi, Hasti Hasheminejad, David J. Lampert

《环境科学与工程前沿（英文）》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1278-1

摘要： Abstract • Graphite bipolar electrodes act as an appropriate bed for the CDI process. • Activated carbon Coating improves the application of the electrodes. • CDI is an environmentally friendly method to apply for brackish water. • Initial concentration is the most important parameter in the CDI method. • CDI process in a batch-mode setup needs more development. This research investigates a capacitive deionization method for salinity reduction in a batch reactor as a new approach for desalination. Reductions of cost and energy compared with conventional desalination methods are the significant advantages of this approach. In this research, experiments were performed with a pair of graphite bipolar electrodes that were coated with a one-gram activated carbon solution. After completing preliminary tests, the impacts of four parameters on electrical conductivity reduction, including (1) the initial concentration of feed solution, (2) the duration of the tests, (3) the applied voltage, and (4) the pH of the solution, were examined. The results show that the maximum efficiency of electrical conductivity reduction in this laboratory-scale reactor is about 55%. Furthermore, the effects of the initial concentration of feed solution are more significant than the other parameters. Thus, using the capacitive deionization method for water desalination with low and moderate salt concentrations (i.e., brackish water) is proposed as an affordable method. Compared with conventional desalination methods, capacitive deionization is not only more efficient but also potentially more environmentally friendly.

关键词： Capacitive deionization (CDI)     Desalination     Electrical conductivity (EC)     Graphite bipolar electrode     Activated carbon coated (ACC)    

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Cream coated on endotracheal tube with or without epidural lidocaine reduces isoflurane requirement during

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 302-306 doi: 10.1007/s11684-012-0194-6

摘要：

This study was designed to evaluate the effect of tracheal topical anesthesia using EMLA? Cream (EC) coated on the endotracheal tube (ETT) with or without epidural anesthesia (EA) on isoflurane requirement during general anesthesia (GA) and investigate whether EC coated on the ETT with EA was associated with the additive effect compared with the effect when each anesthetic was administered independently. The prospective randomized, double-blinded, and controlled study included 60 ASA I–II patients scheduled for upper abdominal surgery requiring GA. Patients were randomly assigned to one of the following groups: group 1 received GA, group 2 received EC+ GA, group 3 received GA+ EA, and group 4 received EC+ GA+ EA. Isoflurane was administered at the required concentrations to maintain the mean arterial pressure at a level not exceeding 20% of preoperative values. The percentage mean expired concentration (%MEC) was used in calculating the isoflurane requirement. Emergence agitation, postoperative sore throat, and hoarseness were recorded. Groups 2, 3, and 4 exhibited a significant reduction on isoflurane requirement compared with group 1 (P<0.05). The isoflurane requirement evaluated by %MEC decreased by 12%, 38%, and 50% in groups 2, 3, and 4, respectively. The incidence of emergence agitation was significantly lower in groups 2 and 4 than those in groups 1 and 3 (P<0.05). Tracheal topical anesthesia using EC coated on ETT with or without EA reduced the isoflurane requirement during GA, indicating that EC combined with EA exhibited an additive effect on the requirement of general anesthetic.

关键词： EMLA? Cream     epidural anesthesia     general anesthesia     isoflurane     lidocaine    

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Long-term durability of onshore coated concrete —chloride ion and carbonation effects

Seyedhamed SADATI,Mehdi K. MORADLLO,Mohammad SHEKARCHI

《结构与土木工程前沿（英文）》 2016年 第10卷 第2期   页码 150-161 doi: 10.1007/s11709-016-0341-2

摘要： Enhancing service life of reinforced concrete (RC) structures located in marine environments is an issue of great interest for design engineers. The present research addresses the effect of surface coatings on service life of onshore RC structures. Long-term performance of concrete samples up to 88 months of exposure at natural marine environment was investigated. Two onshore exposure conditions, including soil and atmosphere and different types of concrete coatings were studied. Carbonation rates of up to 0.5 and 1.5 mm/year were observed at the first 88 months of exposure for soil and atmospheric samples, respectively. Surface chloride ion build-up and variation in chloride ion diffusion were monitored with respect to time, and service life was estimated. Based on the obtained results it is proposed to use the aliphatic acrylic and polyurethane coatings for enhancing the service life of concrete structures in the investigated exposure conditions.

关键词： carbonation     chloride ion     corrosion     service life     surface coating    

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Catalytic cracking of endothermic fuels in coated tube reactor

LI Jia, ZOU Jijun, ZHANG Xiangwen, GUO Wei, MI Zhentao

《化学科学与工程前沿（英文）》 2008年 第2卷 第2期   页码 181-185 doi: 10.1007/s11705-008-0032-1

摘要： Suspensoid of HZSM-5 or HY zeolites mixed with a self-made ceramic-like binder was coated on the inner wall of a tubular reactor by gas-aided fluid displacement technology. The coated zeolites were characterized by means of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The coating thickness is 10–20 ?m and the particle size of the zeolites is in the range of 1–5 ?m. In the coated reactor, cracking of endothermic fuels including -dodecane and aviation fuel RP-3 was carried out separately under supercritical conditions at 600°C and 625°C to investigate their heat sinks and conversion of catalytic reactions. For the reaction catalyzed by HY(25% mass fraction) coating, the heat sink capacity of -dodecane are 815.7 and 901.9 kJ/kg higher than that of the bare tube at 600°C and at 625°C, respectively. Conversion of -dodecane also increases from 42% to 60% at 600°C and from 66% to 80% at 625°C. The coated zeolite can significantly inhibit the carbon deposition during supercritical cracking reactions.

关键词： HZSM-5     self-made ceramic-like     gas-aided     Conversion     Suspensoid    

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Prevalence of antifolate drug resistance markers in in China

《医学前沿（英文）》 2022年 第16卷 第1期   页码 83-92 doi: 10.1007/s11684-021-0894-x

摘要： The dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drug resistance surveillance. A total of 375 P. vivax isolates collected from different geographical locations in China in 2009–2019 were used to sequence Pvdhfr and Pvdhps. The majority of the isolates harbored a mutant type allele for Pvdhfr (94.5%) and Pvdhps (68.2%). The most predominant point mutations were S117T/N (77.7%) in Pvdhfr and A383G (66.8%) in Pvdhps. Amino acid changes were identified at nine residues in Pvdhfr. A quadruple-mutant haplotype at 57, 58, 61, and 117 was the most frequent (57.4%) among 16 distinct Pvdhfr haplotypes. Mutations in Pvdhps were detected at six codons, and the double-mutant A383G/A553G was the most prevalent (39.3%). Pvdhfr exhibited a higher mutation prevalence and greater diversity than Pvdhps in China. Most isolates from Yunnan carried multiple mutant haplotypes, while the majority of samples from temperate regions and Hainan Island harbored the wild type or single mutant type. This study indicated that the antifolate resistance levels of P. vivax parasites were different across China and molecular markers could be used to rapidly monitor drug resistance. Results provided evidence for updating national drug policy and treatment guidelines.

关键词： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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标题 作者 时间 类型 操作

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

期刊论文

Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical

Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang

期刊论文

Carbon-coated Ni-Co alloy catalysts: preparation and performance for aqueous phase hydrodeoxygenation

期刊论文

Spray-coated SnO

Yaqin Wang, Lin Yang, Chunxiang Dall’Agnese, Gang Chen, Ai-Jun Li, Xiao-Feng Wang

期刊论文

Taking advantage of drug resistance, a new approach in the war on cancer

null

期刊论文

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

期刊论文

Development of highly active coated monolith SCR catalyst with strong abrasion resistance for low-temperature

Lina GAN,Shan LEI,Jian YU,Hongtao MA,Yo YAMAMOTO,Yoshizo SUZUKI,Guangwen XU,Zhanguo ZHANG

期刊论文

Protein microspheres for pulmonary drug delivery

Yongda SUN,

期刊论文

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

期刊论文

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

期刊论文

Performance of activated carbon coated graphite bipolar electrodes on capacitive deionization method

Hossein D. Atoufi, Hasti Hasheminejad, David J. Lampert

期刊论文

Cream coated on endotracheal tube with or without epidural lidocaine reduces isoflurane requirement during

null

期刊论文

Long-term durability of onshore coated concrete —chloride ion and carbonation effects

Seyedhamed SADATI,Mehdi K. MORADLLO,Mohammad SHEKARCHI

期刊论文

Catalytic cracking of endothermic fuels in coated tube reactor

LI Jia, ZOU Jijun, ZHANG Xiangwen, GUO Wei, MI Zhentao

期刊论文

Prevalence of antifolate drug resistance markers in in China

期刊论文